Dr Marieke Oudelaar, Stevenson Junior Research Fellow, has just published a paper in Nature Communications on “Dynamics of the 4D genome during in vivo lineage specification and differentiation.”

The paper explores the use of Tiled-C, a 3C adaptation which can generate high-resolution contact matrices at regions of interest and works well in as few as 2,000 cells. The team then combined Tiled-C with ATAC-seq and single-cell RNA-seq to study the relationship between genome structure and function in sequential stages of in vivo erythroid differentiation in mice.

Dr Oudelaar is based at the MRC Weatherall Institute of Molecular Medicine and is part of the Higgs Group: Laboratory of Gene Regulation and the Hughes Group: Genome Biology. Her research focuses on the mechanisms by which the regulatory elements of the genome control tissue-specific gene expression patterns.

“Dynamics of the 4D genome” is available to read online. You can find out more about Marieke in her profile where she discusses one of the biggest mysteries of life! She is also active on Twitter.

Published: 2 July 2020

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