Sarah Jenkinson

Stipendiary Lecturer in Organic Chemistry

Teaching

I teach all 3 years of the Organic Chemistry course at Univ, as well as the 1st year Organic Chemistry course for the Biochemists. I also co-organise and lecture the 1st year Organic Chemistry course for the Department of Biochemistry.

Research

My research is focused in the area of carbohydrate chemistry with an emphasis on the synthesis of rare and branched sugars as building blocks for drug development. Specific targets include diabetes and cystic fibrosis drugs as well as anti-cancer agents.

Selected Publications

Glawar, A. F. G.; Martínez, R. F.; Ayers, B. J.; Hollas, M. A.; Ngo, N.; Nakagawa, S.; Kato, A.; Butters, T.D.; Fleet, G. W. J.; Jenkinson, S. F., Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids, Org. Biomol. Chem. 2016, 14, 10371-10385.

Liu, Z.; Yoshihara, A.; Jenkinson, S. F.; Wormald, M. R.; Estevez, R. J.; Fleet, G. W. J.; Izumori, K., Triacetonide of Glucoheptonic Acid in the Scalable Syntheses of D-Gulose, 6-Deoxy-D-gulose, L-Glucose, 6-Deoxy-L-glucose and Related Sugars, Org. Lett. 2016, 18, 4112–4115.

Liu, Z.; Jenkinson, S. F.; Kato, A.; Nakagawa, S.; Wormald, M. R.; Yu, C.-Y.; Fleet, G. W. J., Azidoazetidines as the first scaffolds for β-amino azetidine carboxylic acid peptidomimetics: azetidine iminosugars containing an acetamido group do not inhibit β-N-acetylhexosaminidases, Tetrahedron: Asymmetry 2016, 27, 872-881.

Liu, Z.; Jenkinson, S. F.; Vermaas, T.; Adachi, I.; Wormald, M. R.; Hata, Y.; Kurashima, Y.; Kaji, A.; Yu, C.-Y.; Kato, A.; Fleet, G. W. J., 3-Fluoro-azetidine Carboxylic Acids and trans,trans-3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar, J. Org. Chem. 2015, 80, 4244–4258.

Ayers, B. J.; Glawar, A. F. G.; Martínez, R. F.; Ngo, N.; Liu, Z.; Fleet, G. W. J.; Butters, T. D.; Nash, R. J.; Yu, C.-Y.; Wormald, M. R.; Nakagawa, S.; Adachi, I.; Kato, A.; Jenkinson, S. F., 9 of 16 Stereoisomeric Polyhydroxylated Proline Amides are Potent β-N-Acetylhexosaminidase Inhibitors, J. Org. Chem. 2014, 79, 3398-3409.

Martínez, R. F.; Liu, Z.; Glawar, A. F. G; Yoshihara, A.; Izumori, K.; Fleet, G. W. J.; Jenkinson, S. F., Short and Sweet: D-Glucose to L-Glucose and L-Glucuronic Acid, Angew. Chem. Int. Edit. 2014, 53, 1160-1162; Kurz und Knapp: L-Glucose und L-Gluconsaure von D-Glucose, Angew. Chem. 2014, 126, 1179-1182.

Glawar, A. F. G.; Jenkinson, S. F.; Newberry, S. J.; Thompson, A. L.; Nakagawa, S.; Yoshihara, A.; Akimitsu, K.; Izumori, K.; Butters, T. D.; Kato, A.; Fleet, G. W. J., An approach to 8 stereoisomers of homonojirimycin from D-glucose via kinetic & thermodynamic azido-g-lactones, Org. Biomol. Chem. 2013, 11, 6886-6889.

Jenkinson, S. F., Best, D., Saville, A. W., Mui, J., Martínez, R. F., Nakagawa, S., Kunimatsu, T., Alonzi, D. S., Butters, T. D., Norez, C., Becq, F., Blériot, Y., Wilson, F. X., Weymouth-Wilson, A. C., Kato, A., Fleet, G. W. J., C-Branched Iminosugars: α-Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP and isoDAB – L-isoDMDP Compared to Miglitol and Miglustat, J. Org. Chem. 2013, 78, 7380-7397.

Jenkinson, S. F.; Fleet, G. W. J.; Nash, R. J.; Koike, Y.; Adachi, I.; Yoshihara, A.; Morimoto, K.; Izumori, K.; Kato, A., Looking-glass synergistic pharmacological chaperones: DGJ and L-DGJ from the enantiomers of tagatose, Org. Lett. 2011, 13, 4064–4067.

Jenkinson, S. F.; Fleet, G. W. J. Oxetanes from the ring contraction of α-triflates of g-lactones: oxetane nucleosides and oxetane amino acids, Chimia 2011, 65, 71-75.